BITTER ORANGE EXTRACT HESPERIDIN
Hesperidin is a plant chemical that is classified as a “bioflavonoid.” It is found primarily in citrus
fruits. People use it as medicine.Hesperidin alone, or in combination with other citrus
bioflavonoids (diosmin, for example), is most often used for blood vessel conditions such as
hemorrhoids,varicose veins, and poor circulation (venous stasis). It is also used to treat
lymphedema, a condition involving fluid retention that can be a complication of breast cancer
Bitter Orange Extract
Bitter Orange Extract
Adrenergic effects: Similar to ephedra, Citrus aurantium contains alkaloids that may have
adrenergic agonist effects, and is often incorporated into supplements claimed to aid in weight
loss. These alkaloids are believed to primarily be alpha-adrenergic agonists, but may also have
some beta-adrenergic agonist properties.
Para-synephrine, often referred to as simply synephrine, has been shown to be an alpha-adrenergic
agonist that may also have beta-adrenergic properties. Para-synephrine occurs naturally in the
human body in small quantities and may act as a neurotransmitter. Para-synephrine is usually
indicated under the name oxedrine. Oxedrine is thought to be the primary ingredient in
Citrus aurantium that produces weight loss, although it has not been firmly established.
Antibacterial effects: Bitter orange preparations are reported to have a variety of antimicrobial
properties. Based on laboratory study, bitter orange peel oil may have insecticidal activity.
Anti-inflammatory effects: Bitter orange peel may have anti-inflammatory activity, which might
be due to the flavonoids naringin and nobiletin. Nobiletin suppressed the interleukin 1 (IL-1)
induced production of proMMP-9/progelatinase B in synovial cells and most effectively suppressed
proMMP-9 production along with the decrease in its mRNA. Nobiletin also reduced IL-1 induced
production of PGE2 in the synovial cells, but did not modify the synthesis of total protein.
Antitumor effects: Preliminary research indicates that bitter orange constituents auraptene,
marmin, tangeretin, nobiretin, and a psoralen compound, might have antitumor effects.
Antiviral effects: Two flavonoids of the bitter orange fruit, neohesperidin and hesperidin, are
reported to have antiviral activity against rotavirus infection
Cardiovascular effects: In animal models, bitter orange caused vasoconstriction and increased
mean arterial pressure (MAP), but reduced portal pressure. Synephrine given intravenously in
men increases systolic blood pressure, but did not increase diastolic blood pressure or heart rate.
Poor circulation in the legs (chronic venous insufficiency, CVI). Taking a particular product
containing hesperidin methyl chalcone, butcher's broom, and vitamin C by mouth seems to relieve
the symptoms of poor circulation in the legs.
Hemorrhoids. Taking a specific product (Daflon 500, Les Laboratoires Servier) containing
hesperidin and diosmin by mouth for up to 3 months improves symptoms of anal hemorrhoids.
Leg ulcers from poor circulation (venous stasis ulcers).
Treating swelling of the arms following surgery for breast cancer.